fabF [2019-07-31 09:04:17]

beta-ketoacyl-acyl carrier protein synthase II, involved in the control of membrane fluidity

Locus: BSU_11340

Isoelectric point: 4.77

Molecular weight: 43.84 kDa

Protein length: 413 aa

Gene length: 1242 bp

Function: fatty acid biosynthesis

Product: beta-ketoacyl-acyl carrier protein synthase II

Essential: yes

E.C.: 2.3.1.179

Synonyms: yjaY

Genomic Context

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Categories containing this gene/protein

• Cellular processes → Cell envelope and cell division → Membrane dynamics
• Metabolism → Lipid metabolism → Biosynthesis of lipids → Biosynthesis of fatty acids
• Lifestyles → Coping with stress → Cell envelope stress proteins (controlled by SigM, V, W, X, Y)
• Groups of genes → Essential genes

Gene

Coordinates: 1,209,183 1,210,424

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• (Z)-hexadec-11-enoyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = (Z)-3-oxooctadec-13-enoyl-[acyl-carrier-protein] + CO₂ + [acyl-carrier-protein] (according to Swiss-Prot)
• SigW-dependent expression of fabF and the yuaF-floT-yuaI operon result in reduced membrane fluidity PubMed

Protein family

• thiolase-like superfamily (according to UniProt)

Structure

• 4LS5 PubMed

Expression and Regulation

Operons

• Genes: fabHA-fabF
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon
  • SigW: sigma factor, PubMed, in SigW regulon

  Regulatory mechanism

  • FapR: repression, PubMed, in FapR regulon

  Regulation

  • fabHA: expressed when the cells experience a lack of malonyl-CoA (FapR) PubMed
  • expression of the operon is strongly reduced during biofilm formation PubMed

References

Reviews

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Original Publications

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